Hyaluronic acid

Source: bio-fermentation (produced from bacteria)
Hyaluronic Acid is the most hydrated biopolymer known. In living tissues it serves as a connective tissue organizer and water holding substance. The sodium hyaluronate is coming from a biotechnical safe process; it is free of contaminants and GMO.

A certain level of stratum corneum hydration is essential for skin smoothness and elasticity, as well as for enzyme reactions important for skin renewal and desquamation. Hyaluronic Acid is forming a film on the skin and so hydrates the topical layers of stratum corneum. In addition this film reduces the irritating and negative influences of environment to the skin.

XS Hyaluronic acid

Source: bio-fermentation (produced from bacteria)
Hyaluronic Acid is the most hydrated biopolymer known. In living tissues it serves as a connective tissue organizer and water holding substance. The sodium hyaluronate is coming from a biotechnical safe process; it is free of contaminants and GMO.

XS Hyaluronic Acid which is a very low molecular weight hyaluronic acid. It is a breakthrough in anti-aging properties with increased permeation through the skin compared to high molecular weight hyaluronic acid. It rejuvenates the skin by improving its viscoelastic properties and significantly decreases deep wrinkles.

Acetyl Glutamine

Source: natural
It is non-essential and conditionally essential amino acid, meaning the body can usually synthesize sufficient amounts of it, but in some instances of stress, the body's demand for glutamine increases, and glutamine must be obtained from the diet.

In blood, glutamine is the most abundant free amino acid. Glutamine helps skin cells function optimally for smooth, radiant, healthy-looking skin. Furthermore, Glutamine is scientifically proven to play an important role in the growth of fibroblast cells.

Collagen is the protein that gives skin its youthful firmness, and it makes up 75% of our skin. As we age, the amount of collagen that we naturally produce begins to decline, and therefore, the breakdown of collagen and exposure of skin to damaging ultraviolet radiation from the sun leads to the formation of wrinkles and sagging skin. Glutamine helps to reverse these effects of aging by significantly increasing collagen production within the skin – reversing the effects of aging, restoring skin's natural tone, and smoothing out the texture. Acetyl glutamine is an improved form of glutamine

Retinol (Vitamin A)

Source: synthesis
Regulates the processes of differentiation , proliferation and intercellular communication. When it get into a cell, it can make a bond with nuclear sensors. Thus, sections of the cell genome are activated or decelerated. Retinol provides minimal skin damage, a brief recovery period and a low probability of complications. Retinol can effectively cleanse the skin, has anti-inflamatory effects, makes skin glow, improves skin texture and structure, and provides a lifting effect.

Niacinamide (Vitamin B3)

Source: natural
Niacinamide (nicotinamide) comprises one of the two forms of Vitamin B3; niacin (or nicotinic acid) being the other, both of which provide equivalent vitamin activity. As an essential component of living cells, Vitamin B3 is essential for protein, carbohydrate and fat metabolism.

Niacinamide is a precursor in the synthesis of the pyridine coenzymes NAD and NADP involved in cell metabolism, and as such play a key role in the production of energy. Key attributes:
• Upregulates Aquaporin-3 (AQP3) (in vitro)
• Enhances skin tone (in vitro)
• Helps improve the overall appearance of skin
• Improving skin texture
• Evening skin complexion
• May help to reduce the appearance of acne
• May help to revitalize hair to minimize hair fall and improve its overall appearance

Panthenol (Vitamin B5)

Source: natural
DL-Panthenol is the provitamin of DL-Pantothenic acid (Vitamin B5), which plays a key role in the human intermediary metabolism. Deficiency of Vitamin B5 can result in many dermatological disorders.

DL-Panthenol is applied in almost all types of cosmetic preparations. It cares hair, skin and nails. It acts as a skin conditioning agent to provide deep penetrating moisture to the skin, stimulating epithelisation to provide wound healing and anti-inflammatory effects. It also functions as a hair conditioning agent to provide long lasting moisture to hair, preventing damage, thicken hair and improve luster and sheen. This product can also be used in nail care products to improve hydration and impart flexibility.

Folic acid (Vitamin B9)

Source: natural
Because folic acid helps to facilitate the development of healthy skin cells, it can help fight out premature aging, specifically wrinkles and fine lines. It has also been found to increase the production of collagen to give you firmer and more toned skin.

Folic acid, also known as vitamin B9, works like an antioxidant to promote cell turnover and fight free radical damage. Studies have also shown that when applied topically along with creatine, it fights signs of sun damage and aging, leading to firmer looking skin.

ET-vitamin C

Source: synthesis
Et-Vitamin C is a multi-functional vitamin C derivative with excellent whitening, anti-oxidation, free radical- scavenging and collagen boosting effect. Its stability is superior to other ascorbic acid derivatives. It exhibits strong inhibition effect on melanogenesis, reduces dark spots and age spots, fights photoaging by interfering with inflammatory cytokines and reverse ROS production to achieve free radical scavenging purpose.

Tocopherol (Vitamin E )

Source: natural
Tocopherol is a form of Vitamin E typically derived from vegetable oils.T ocopherol is known as an antioxidant superhero that provides protection for skin. (This shouldn’t be terribly surprising, since tocopherols make up 96% of skin’s natural antioxidant defence system!).

Studies show tocopherol: Absorbs UV rays and helps prevent UV-induced free radical damage to skin. Acts as an anti-inflammatory agent in skin. Helps moisturise. Helps reduce pollution-related free radical damage. There’s also preliminary evidence that it can help prevent scarring and reduce the signs of aging, too.

Souce: natural extract from sea algae.

A natural UVA-screening compound from sea algae to protect the skin against photo-aging. Unlike UVB, UVA is much less dependent on the time of the day or the season and penetrates clouds and glass.

UVA is the major cause of premature skin-aging manifested by deep wrinkles and loss of resilience. Thus, our skin needs permanent protection against UVA. Ingredients that are applied on a daily basis need to be absolutely safe.

Helioguard 365 is a natural, safe alternative to synthetic sun filters for the use in anti-aging products. Helioguard 365 consists of sun-screening compounds from the red alga Porphyra umbilicalis. They protect the skin efficiently against premature aging.

Ultraviolet light, the invisible part of sunlight.

Sunlight is composed of ultraviolet (UV), visible light and infrared. UV-light is harmful to all organisms. The energy-rich radiation damages organic molecules like proteins, lipids and DNA and leads to the formation of free radicals.
UV light can be separated into UVB and UVA.

The short wavelength of UVB is absorbed in the epidermis. UVB is responsible for sunburn and can cause skin cancer. UVA, with longer wavelengths penetrates deeper into the skin, causing damage to the dermis. UVA produces free radicals that lead to the breakdown of the proteins collagen and elastin, the most important structural components responsible for the firmness and resilience of the skin.

Unlike UVB, UVA is only partially absorbed by glass and clouds and is less dependent on the time of the day, the season and geography. But about 40% of the outdoor UVA radiation is still received indoors.

The red alga porphyra umbilicalis contains natural UVA filters. Algae that live on the seashores are very exposed to sunlight. Thus certain algae developed most effective UV-screening compounds. The red alga porphyra umbilicalis, also known as "red laver" or nori, grows on rocky shores. The Porphyra species are a rich source of proteins, vitamins and minerals and therefore commecialized as sea-vegetables.

Unfortunately, Porphyra umbilicalis contains only low concentrations of the UVA-absorbing substances porphyra-334 and shinorine that belong to the mycosporine-like amino acids (MAA). For the production of Helioguard 365 these MAAs are concentrated and incorporated into liposomes.

For both compounds, Porphyra and shinorine, the maximum of absorption is at 334 nm. The extinction coefficient of both is between 40'000 and 45'000. Therefore, these two MAAs have the same absorption capacities as commercial, synthetic UVA-filters.

- Helioguard 365 is a safe and efficient ingredient against premature skin-aging. - Helioguard 365 exerts a significant SPF-boosting activity

- Helioguard 365 shows clear protection against UV-induced DNA damage

Souce: Synthesis.

Vitaminated matrikine biotinyl-Gly-His-Lys in association with provitamin B5 (panthenol). Widelash helps eyelashes appear longer, fuller and stronger by promoting hair bulb keratinocyte proliferation and ensuring optimal hair anchorage. It stimulates the synthesis and organization of the adhesion molecules laminin 5 and collagen IV.

The tripeptide GHK, naturally found in the human body, promotes the wound- healing processes.

Double-blind clinical study with 30 female volunteers applying daily a product containing Widelash on one eye versus placebo on the other one. Measurements by image analysis at T0, 15 days and 30 days. Evaluation by trained experts and self-evaluation after 30 days.

- Length of eye lash increased by 43% after 30 days.

- Diameter of eye lash increased by 40% after 30 days.